Predictors of hypertension and changes of blood pressure in HIV-infected patients
Identifieur interne : 00A492 ( Main/Exploration ); précédent : 00A491; suivant : 00A493Predictors of hypertension and changes of blood pressure in HIV-infected patients
Auteurs : Rodolphe Thiebaut [France] ; Wafaa M. El-Sadr [États-Unis] ; Nina Friis-M Ller [Danemark] ; Martin Rickenbach [Suisse] ; Peter Reiss [Pays-Bas] ; Antonella D'Arminio Monforte [Italie] ; Linda Morfeldt [Suède] ; Eric Fontas [France] ; Ole Kirk [Danemark] ; Stephane De Wit [Belgique] ; Gonzalo Calvo [Espagne] ; Matthew G. Law [Australie] ; Francois Dabis [France] ; Caroline A. Sabin [Royaume-Uni] ; Jens D. Lundgren [Danemark]Source :
- Antiviral therapy : (London) [ 1359-6535 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Objective: We assessed predictors of changes in systolic (SBP) and diastolic (DBP) blood pressure during follow-up and of the development of hypertension in HIV-infected individuals. Methods: International cohort collaborative study (D:A:D) of established prospective cohorts of HIV-1-infected patients. Longitudinal analysis of changes in blood pressure (BP) was performed using mixed effects models in 17170 patients. Predictors of development of hypertension during follow-up (systolic BP ≥140 and/or diastolic BP ≥90 mmHg or initiation of antihypertensive treatment) were assessed using Cox models in 8 984 patients with a normal BP level at baseline. Results: 73548 BP measurements with a median of 4 per patient (interquartile range [IQR]: 2-6) were recorded over a median follow-up of 2.3 years (IQR: 1.5-2.6). Risk factors significantly associated with a development of higher systolic BP and diastolic BP (differences ≥5 mmHg and P-values <0.001) during follow-up were: older age, male sex, higher body mass index (BMI) and use of BP-lowering drugs. In patients with normal BP at baseline, 1186 developed hypertension for an incidence of 72.1 per 1000 person-years (95% confidence interval: 68.2-76.0). Factors associated with development of hypertension were: male sex, higher BMI, older age, higher BP at baseline, high total cholesterol and clinical lipodystrophy. Cumulative duration of exposure to nucleoside reverse transcriptase inhibitors (P=0.75), protease inhibitors (P=0.92) as well as type of antiretroviral treatment at baseline (P=0.18) were not associated with a higher risk of hypertension. Cumulative duration of exposure to non-nucleoside reverse transcriptase inhibitors (NNRTIs) was significantly associated with lower risk of hypertension (hazard ratio=0.78 and 0.67 for those treated ≤10 months and >10 months compared with no exposure; P=0.005). Conclusions: Increased blood pressure in HIV-infected individuals is associated with established risk factors for hypertension. There was no evidence for an independent deleterious effect of any class of antiretroviral drugs on BP, although the use of NNRTIs was associated with a lower risk of development of hypertension.
Affiliations:
- Australie, Belgique, Danemark, Espagne, France, Italie, Pays-Bas, Royaume-Uni, Suisse, Suède, États-Unis
- Angleterre, Aquitaine, Canton de Vaud, Catalogne, Grand Londres, Hollande-Septentrionale, Hovedstaden, Lombardie, Nouvelle-Aquitaine, Nouvelle-Galles du Sud, Provence-Alpes-Côte d'Azur, Région de Bruxelles-Capitale, Svealand
- Amsterdam, Barcelone, Bordeaux, Bruxelles, Copenhague, Lausanne, Londres, Milan, Nice, Stockholm, Sydney
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El-Sadr</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Community Program for Clinical Research on AIDS (CPCRA), Columbia University/Harlem Hospital</s1><s2>New York, NY</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Friis M Ller, Nina" sort="Friis M Ller, Nina" uniqKey="Friis M Ller N" first="Nina" last="Friis-M Ller">Nina Friis-M Ller</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Copenhagen HIV Programme (CHIP), Hvidovre University Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Rickenbach, Martin" sort="Rickenbach, Martin" uniqKey="Rickenbach M" first="Martin" last="Rickenbach">Martin Rickenbach</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>SHCS, Division of Epidemiology, Centre Hospitalier Universitaire Vaudois</s1><s2>Lausanne</s2><s3>CHE</s3><sZ>4 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>ATHENA, HIV Monitoring Foundation, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>5 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="D Arminio Monforte, Antonella" sort="D Arminio Monforte, Antonella" uniqKey="D Arminio Monforte A" first="Antonella" last="D'Arminio Monforte">Antonella D'Arminio Monforte</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>ICONA, L Sacco Hospital, University of'Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Morfeldt, Linda" sort="Morfeldt, Linda" uniqKey="Morfeldt L" first="Linda" last="Morfeldt">Linda Morfeldt</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>HivBivus, Karolinska Hospital</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>7 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Fontas, Eric" sort="Fontas, Eric" uniqKey="Fontas E" first="Eric" last="Fontas">Eric Fontas</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Nice Cohort, CHU Nice Hopital de l'Archet</s1><s2>Nice</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>EuroSIDA, CHIP, Hvidovre University Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>9 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stephane" last="De Wit">Stephane De Wit</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Saint-Pierre Cohort, CHU Saint-Pierre Hospital</s1><s2>Brussels</s2><s3>BEL</s3><sZ>10 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Calvo, Gonzalo" sort="Calvo, Gonzalo" uniqKey="Calvo G" first="Gonzalo" last="Calvo">Gonzalo Calvo</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>BASS, Autonomous University of Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>11 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Law, Matthew G" sort="Law, Matthew G" uniqKey="Law M" first="Matthew G" last="Law">Matthew G. Law</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>AHOD, National Centre in HIV Epidemiology and Clinical Research</s1><s2>Sydney</s2><s3>AUS</s3><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM E0338 & U593, ISPED, Université Victor Segalen Bordeaux 2</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A" last="Sabin">Caroline A. Sabin</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College</s1><s2>London</s2><s3>GBR</s3><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D" last="Lundgren">Jens D. Lundgren</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Copenhagen HIV Programme (CHIP), Hvidovre University Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0008618</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 06-0008618 INIST</idno><idno type="RBID">Pascal:06-0008618</idno><idno type="wicri:Area/PascalFrancis/Corpus">004648</idno><idno type="wicri:Area/PascalFrancis/Curation">001A47</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">004439</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">004439</idno><idno type="wicri:doubleKey">1359-6535:2005:Thiebaut R:predictors:of:hypertension</idno><idno type="wicri:Area/Main/Merge">00B089</idno><idno type="wicri:Area/Main/Curation">00A492</idno><idno type="wicri:Area/Main/Exploration">00A492</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Predictors of hypertension and changes of blood pressure in HIV-infected patients</title><author><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiebaut">Rodolphe Thiebaut</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM E0338 & U593, ISPED, Université Victor Segalen Bordeaux 2</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="El Sadr, Wafaa M" sort="El Sadr, Wafaa M" uniqKey="El Sadr W" first="Wafaa M" last="El-Sadr">Wafaa M. El-Sadr</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Community Program for Clinical Research on AIDS (CPCRA), Columbia University/Harlem Hospital</s1><s2>New York, NY</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Friis M Ller, Nina" sort="Friis M Ller, Nina" uniqKey="Friis M Ller N" first="Nina" last="Friis-M Ller">Nina Friis-M Ller</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Copenhagen HIV Programme (CHIP), Hvidovre University Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Rickenbach, Martin" sort="Rickenbach, Martin" uniqKey="Rickenbach M" first="Martin" last="Rickenbach">Martin Rickenbach</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>SHCS, Division of Epidemiology, Centre Hospitalier Universitaire Vaudois</s1><s2>Lausanne</s2><s3>CHE</s3><sZ>4 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>ATHENA, HIV Monitoring Foundation, Academic Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>5 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="D Arminio Monforte, Antonella" sort="D Arminio Monforte, Antonella" uniqKey="D Arminio Monforte A" first="Antonella" last="D'Arminio Monforte">Antonella D'Arminio Monforte</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>ICONA, L Sacco Hospital, University of'Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>6 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Morfeldt, Linda" sort="Morfeldt, Linda" uniqKey="Morfeldt L" first="Linda" last="Morfeldt">Linda Morfeldt</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>HivBivus, Karolinska Hospital</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>7 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Fontas, Eric" sort="Fontas, Eric" uniqKey="Fontas E" first="Eric" last="Fontas">Eric Fontas</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Nice Cohort, CHU Nice Hopital de l'Archet</s1><s2>Nice</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>EuroSIDA, CHIP, Hvidovre University Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>9 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stephane" last="De Wit">Stephane De Wit</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Saint-Pierre Cohort, CHU Saint-Pierre Hospital</s1><s2>Brussels</s2><s3>BEL</s3><sZ>10 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Calvo, Gonzalo" sort="Calvo, Gonzalo" uniqKey="Calvo G" first="Gonzalo" last="Calvo">Gonzalo Calvo</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>BASS, Autonomous University of Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>11 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Law, Matthew G" sort="Law, Matthew G" uniqKey="Law M" first="Matthew G" last="Law">Matthew G. Law</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>AHOD, National Centre in HIV Epidemiology and Clinical Research</s1><s2>Sydney</s2><s3>AUS</s3><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM E0338 & U593, ISPED, Université Victor Segalen Bordeaux 2</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A" last="Sabin">Caroline A. Sabin</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College</s1><s2>London</s2><s3>GBR</s3><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D" last="Lundgren">Jens D. Lundgren</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Copenhagen HIV Programme (CHIP), Hvidovre University Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>3 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Antiviral therapy : (London)</title><title level="j" type="abbreviated">Antivir. ther. : (Lond.)</title><idno type="ISSN">1359-6535</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Antiviral therapy : (London)</title><title level="j" type="abbreviated">Antivir. ther. : (Lond.)</title><idno type="ISSN">1359-6535</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Arterial pressure</term><term>Blood pressure</term><term>Hypertension</term><term>Predictive factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Facteur prédictif</term><term>Hypertension artérielle</term><term>Pression sanguine</term><term>Pression artérielle</term><term>SIDA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: We assessed predictors of changes in systolic (SBP) and diastolic (DBP) blood pressure during follow-up and of the development of hypertension in HIV-infected individuals. Methods: International cohort collaborative study (D:A:D) of established prospective cohorts of HIV-1-infected patients. Longitudinal analysis of changes in blood pressure (BP) was performed using mixed effects models in 17170 patients. Predictors of development of hypertension during follow-up (systolic BP ≥140 and/or diastolic BP ≥90 mmHg or initiation of antihypertensive treatment) were assessed using Cox models in 8 984 patients with a normal BP level at baseline. Results: 73548 BP measurements with a median of 4 per patient (interquartile range [IQR]: 2-6) were recorded over a median follow-up of 2.3 years (IQR: 1.5-2.6). Risk factors significantly associated with a development of higher systolic BP and diastolic BP (differences ≥5 mmHg and P-values <0.001) during follow-up were: older age, male sex, higher body mass index (BMI) and use of BP-lowering drugs. In patients with normal BP at baseline, 1186 developed hypertension for an incidence of 72.1 per 1000 person-years (95% confidence interval: 68.2-76.0). Factors associated with development of hypertension were: male sex, higher BMI, older age, higher BP at baseline, high total cholesterol and clinical lipodystrophy. Cumulative duration of exposure to nucleoside reverse transcriptase inhibitors (P=0.75), protease inhibitors (P=0.92) as well as type of antiretroviral treatment at baseline (P=0.18) were not associated with a higher risk of hypertension. Cumulative duration of exposure to non-nucleoside reverse transcriptase inhibitors (NNRTIs) was significantly associated with lower risk of hypertension (hazard ratio=0.78 and 0.67 for those treated ≤10 months and >10 months compared with no exposure; P=0.005). Conclusions: Increased blood pressure in HIV-infected individuals is associated with established risk factors for hypertension. There was no evidence for an independent deleterious effect of any class of antiretroviral drugs on BP, although the use of NNRTIs was associated with a lower risk of development of hypertension.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Canton de Vaud</li><li>Catalogne</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Hovedstaden</li><li>Lombardie</li><li>Nouvelle-Aquitaine</li><li>Nouvelle-Galles du Sud</li><li>Provence-Alpes-Côte d'Azur</li><li>Région de Bruxelles-Capitale</li><li>Svealand</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Bordeaux</li><li>Bruxelles</li><li>Copenhague</li><li>Lausanne</li><li>Londres</li><li>Milan</li><li>Nice</li><li>Stockholm</li><li>Sydney</li></settlement></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiebaut">Rodolphe Thiebaut</name></region><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name><name sortKey="Fontas, Eric" sort="Fontas, Eric" uniqKey="Fontas E" first="Eric" last="Fontas">Eric Fontas</name></country><country name="États-Unis"><noRegion><name sortKey="El Sadr, Wafaa M" sort="El Sadr, Wafaa M" uniqKey="El Sadr W" first="Wafaa M" last="El-Sadr">Wafaa M. El-Sadr</name></noRegion></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Friis M Ller, Nina" sort="Friis M Ller, Nina" uniqKey="Friis M Ller N" first="Nina" last="Friis-M Ller">Nina Friis-M Ller</name></region><name sortKey="Kirk, Ole" sort="Kirk, Ole" uniqKey="Kirk O" first="Ole" last="Kirk">Ole Kirk</name><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D" last="Lundgren">Jens D. Lundgren</name></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Rickenbach, Martin" sort="Rickenbach, Martin" uniqKey="Rickenbach M" first="Martin" last="Rickenbach">Martin Rickenbach</name></region></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name></region></country><country name="Italie"><region name="Lombardie"><name sortKey="D Arminio Monforte, Antonella" sort="D Arminio Monforte, Antonella" uniqKey="D Arminio Monforte A" first="Antonella" last="D'Arminio Monforte">Antonella D'Arminio Monforte</name></region></country><country name="Suède"><region name="Svealand"><name sortKey="Morfeldt, Linda" sort="Morfeldt, Linda" uniqKey="Morfeldt L" first="Linda" last="Morfeldt">Linda Morfeldt</name></region></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stephane" last="De Wit">Stephane De Wit</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Calvo, Gonzalo" sort="Calvo, Gonzalo" uniqKey="Calvo G" first="Gonzalo" last="Calvo">Gonzalo Calvo</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Law, Matthew G" sort="Law, Matthew G" uniqKey="Law M" first="Matthew G" last="Law">Matthew G. Law</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A" last="Sabin">Caroline A. Sabin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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